Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats.

@article{Yamagishi2001CharacteristicCO,
  title={Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats.},
  author={Nobuyuki Yamagishi and Kaeko Nakayama and Tetsuro Wakatsuki and Takumi Hatayama},
  journal={Life sciences},
  year={2001},
  volume={69 22},
  pages={
          2603-9
        }
}
Stress proteins (heat shock proteins, HSP) play essential roles in folding, assembly and translocation of polypeptides and also in maintenance of the integrity of polypeptides as molecular chaperones. Since long-lasting hyperglycemia causes modification of cellular proteins, it is possible that expression of molecular chaperones may be altered during the course of diabetes. Here, we examined the cellular levels of stress proteins such as HSP105, HSP90 and HSC70/HSP70 in various tissues of… CONTINUE READING