Characteristic Markers of the WNT Signaling Pathways Are Differentially Expressed in Osteoarthritic Cartilage.

@article{Thorfve2012CharacteristicMO,
  title={Characteristic Markers of the WNT Signaling Pathways Are Differentially Expressed in Osteoarthritic Cartilage.},
  author={Anna I Thorfve and T. A. Dehne and A. Lindahl and Mats Brittberg and Axel Pruss and Jochen Ringe and Michael Sittinger and Camilla Karlsson},
  journal={Cartilage},
  year={2012},
  volume={3 1},
  pages={43-57}
}
OBJECTIVE It is well known that expression of markers for WNT signaling is dysregulated in osteoarthritic (OA) bone. However, it is still not fully known if the expression of these markers also is affected in OA cartilage. The aim of this study was therefore to examine this issue. METHODS Human cartilage biopsies from OA and control donors were subjected to genome-wide oligonucleotide microarrays. Genes involved in WNT signaling were selected using the BioRetis database, KEGG pathway analysis… CONTINUE READING

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