Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

@article{Yousry1999CharacteristicML,
  title={Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).},
  author={Tarek Yousry and Klaus Christian Seelos and Michael Mayer and Roland Br{\"u}ning and Ingo Uttner and Martin Dichgans and Silvia Mammi and Andreas M. Straube and Norbert Mai and Massimo Filippi},
  journal={AJNR. American journal of neuroradiology},
  year={1999},
  volume={20 1},
  pages={91-100}
}
BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an arteriopathy related to a genetic defect of the notch 3 gene on chromosome 19. The purpose of this study was to evaluate lesion distribution and volume using MR imaging and to correlate the lesion volume with the neurologic and neuropsychological findings. METHODS Twenty members of two families (14 with CADASIL as determined by linkage analysis, six healthy) were… CONTINUE READING

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