Characteristic Clinicopathological Features of the Types of Intraductal Papillary-Mucinous Neoplasms of the Pancreas

  title={Characteristic Clinicopathological Features of the Types of Intraductal Papillary-Mucinous Neoplasms of the Pancreas},
  author={Masaharu Ishida and Shin‐ichi Egawa and Takeshi Aoki and Naoaki Sakata and Yukio Mikami and Fuyuhiko Motoi and Tadayoshi Abe and Shoji Fukuyama and Makoto Sunamura and Michiaki Unno and Takuya Moriya and Akira Horii and Toru Furukawa},
Objectives: Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas encompasses a spectrum of neoplasms with both morphological and immunohistochemical variations of mucin glycoproteins. Recently, a consensus nomenclature and criteria were histologically defined for classifying these variants of IPMNs into gastric, intestinal, pancreatobiliary, and oncocytic types. The purpose of this study was to determine associations between the histological types and clinicopathological features in… 
Intraductal Papillary-Mucinous Neoplasms of the Gastric and Intestinal Types May Have Less Malignant Potential Than the Pancreatobiliary Type
Intraductal papillary-mucinous neoplasm of the gastric and intestinal types may have less malignant potential than that of the pancreatobiliary type.
Prognostic value of histological subtype in intraductal papillary mucinous neoplasm of the pancreas
Histological subtype had limited prognostic value in patients with IPMNs, and the main prognostic factor for patients with invasive IPMNs was the lymph-node status, so the association between nerve invasion and overall survival lost statistical significance after multivariate analysis.
Evaluation of Clinical Meaning of Histological Subtypes of Intraductal Papillary Mucinous Neoplasm of the Pancreas
Although histological subtypes are associated with the degree of dysplasia, histology subtypes have limited prognostic value for pancreatic IPMNs.
Preoperative Histological Subtype Classification of Intraductal Papillary Mucinous Neoplasms (IPMN) by Pancreatic Juice Cytology With MUC Stain
Preoperative PJC with MUC stain proved to be highly reliable for identifying the histological subtype of IPMN and may provide useful information for deciding surgical indication.
Clinicopathologic Features of Intraductal Papillary Neoplasm of the Bile Duct According to Histologic Subtype
Gastric and intestinal types of IPN-B have similar clinical characteristics compared with the pancreaticobiliary type, which has a worse prognosis.
Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature
There are no reliable criteria other than histopathological picture and K-ras gene status to differentiate IOPN from IPMN, and several differences in the clinical and biological profile between IOPn and IPMN exist, but they are of quantitative rather than of qualitative nature.
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
Analysis of these subtypes indicates that the background epithelium plays an equally, if not more, important role in defining the biology and prognosis of invasive IPMNs, and arise from different epithelial subtypes.
Intraductal Papillary Mucinous Neoplasms Often Contain Epithelium From Multiple Subtypes and/or Are Unclassifiable
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are subclassified into gastric, intestinal, pancreatobiliary, and oncocytic subtypes based on histologic features. The WHO classification


Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
A consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type are defined and can be used for further analyses of the clinicopathological significance of the variations of IPMN.
Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management.
Intraductal papillary mucinous tumors may be composed of 2 clinically distinct subtypes: MDTs and BDTs and the need for cancer-free margins in this more aggressive type may necessitate total pancreatectomy.
An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
The purpose of this meeting was to define an international acceptable set of diagnostic criteria for PanINs and IPMNs and to address a number of ambiguities that exist in the previously reported classification systems for these neoplasms.
The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis
The results here support a dichotomy in the dysplasia–CIS sequence in the pancreas and support the previous impression that MUC2 (the mucin associated with gel formation) is a marker of the “indolent” pathway (intraductal papillary mucinous neoplasm and colloid carcinoma).
The mucus‐hypersecreting tumor of the pancreas. Development and extension visualized by three‐dimensional computerized mapping
Computer‐aided three‐dimensional reconstruction was done of the ductal system to determine where such tumors arise and how they extend and to visualize the spatial relationships among epithelial hyperplasia, dysplasia and carcinoma in situ (CIS).
Japan Pancreas Society. Classification of Pancreatic Carcinoma, 2nd ed
  • Tokyo: Kanehara & Co,
  • 2003