Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies.

@article{Kleberg2010CharacterisingTB,
  title={Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies.},
  author={Karen Kleberg and Jette H Jacobsen and Anette M{\"u}llertz},
  journal={The Journal of pharmacy and pharmacology},
  year={2010},
  volume={62 11},
  pages={1656-68}
}
OBJECTIVES Based on the knowledge of human intestinal fluids, compositions of biorelevant media and their impact on solubility, dissolution and permeability studies of poorly soluble drug compounds are discussed. KEY FINDINGS Human intestinal fluids show large variations with regard to composition and pH, which complicate the selection of biorelevant media. The influence of concentration and ratio of bile salts, phospholipids and hydrolysis products, such as monoglycerides and free fatty… CONTINUE READING
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