Characterising the Mucosal and Systemic Immune Responses to Experimental Human Hookworm Infection

@inproceedings{Gaze2012CharacterisingTM,
  title={Characterising the Mucosal and Systemic Immune Responses to Experimental Human Hookworm Infection},
  author={Soraya Torres Gaze and Henry J McSorley and James Daveson and Di Jones and Jeffrey Michael Bethony and Luciana Maria Oliveira and Richard Speare and James S McCarthy and Christian R Engwerda and John Croese and Alex Loukas},
  booktitle={PLoS pathogens},
  year={2012}
}
The mucosal cytokine response of healthy humans to parasitic helminths has never been reported. We investigated the systemic and mucosal cytokine responses to hookworm infection in experimentally infected, previously hookworm naive individuals from non-endemic areas. We collected both peripheral blood and duodenal biopsies to assess the systemic immune response, as well as the response at the site of adult worm establishment. Our results show that experimental hookworm infection leads to a… CONTINUE READING
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Characterising the mucosal and systemic immune responses to experimental human hookworm infection

R. Speare, J. Croese, A. Loukas
PLoS Pathogens • 2012

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