Characterising metabolically healthy obesity in weight-discordant monozygotic twins

  title={Characterising metabolically healthy obesity in weight-discordant monozygotic twins},
  author={Jussi Naukkarinen and Sini Heinonen and Antti Hakkarainen and J O Jesper Lundbom and Katriina Vuolteenaho and Lilli Saarinen and Sampsa Hautaniemi and Amaia Rodr{\'i}guez and Gema Fr{\"u}hbeck and Pia Pajunen and Tuulia Hy{\"o}tyl{\"a}inen and Matej Ore{\vs}i{\vc} and Eeva Moilanen and Anu Suomalainen and Nina Lundbom and Jaakko M Kaprio and Aila M. Rissanen and Kirsi Hannele Pietil{\"a}inen},
Not all obese individuals display the metabolic disturbances commonly associated with excess fat accumulation. Mechanisms maintaining this ‘metabolically healthy obesity’ (MHO) are as yet unknown. We aimed to study different fat depots and transcriptional pathways in subcutaneous adipose tissue (SAT) as related to the MHO phenomenon. Sixteen rare young adult obesity-discordant monozygotic (MZ) twin pairs (intra-pair difference (∆) in BMI ≥3 kg/m2), aged 22.8–35.8 years, were examined for… CONTINUE READING
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