Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs.

@article{Kgel2014CharacterisationOT,
  title={Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs.},
  author={Babette Y K{\"o}gel and Rolf Terlinden and Johannes P Schneider},
  journal={Veterinary anaesthesia and analgesia},
  year={2014},
  volume={41 3},
  pages={297-304}
}
OBJECTIVE To evaluate the analgesic potential of the centrally acting analgesics tramadol, morphine and the novel analgesic tapentadol in a pre-clinical research model of acute nociceptive pain, the tail-flick model in dogs. STUDY DESIGN Prospective part-randomized pre-clinical research trial. ANIMALS Fifteen male Beagle dogs (HsdCpb:DOBE), aged 12-15 months. METHODS On different occasions separated by at least 1 week, dogs received intravenous (IV) administrations of tramadol (6.81, 10.0… CONTINUE READING
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