Characterisation of the toxic metabolite(s) of naphthalene.

  title={Characterisation of the toxic metabolite(s) of naphthalene.},
  author={A S Wilson and Cindy Dyann Davis and Dominic P Williams and Alan R. Buckpitt and Munir Pirmohamed and Brian Kevin Park},
  volume={114 3},
The toxicity of naphthalene and its metabolites has been investigated in vitro. Both naphthalene and its metabolite 1-naphthol were bioactivated by human hepatic microsomes to metabolite(s) which were toxic to mononuclear leucocytes (MNL). However 1-naphthol was more cytotoxic than naphthalene (49.8 +/- 13.9% vs. 19.0 +/- 10.0% cell death; P < 0.01), indicating that the toxicity of naphthalene is dependent on the bioactivation of 1-naphthol. CYP2E1-induced rat liver microsomes increased… CONTINUE READING
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