Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific function.

@article{Park2005CharacterisationOT,
  title={Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific function.},
  author={Daniel J. Park and Andrew J Pask and Kim Khanh Huynh and Vincent Harley and Marilyn B Renfree and Jennifer A. Marshall Graves},
  journal={Gene},
  year={2005},
  volume={362},
  pages={29-36}
}
Many or most genes on the mammal Y chromosome evolved a testis-specific function after diverging from an X-borne copy with a general function in both sexes. In marsupial but not eutherian mammals, a testis-specific orthologue (ATRY) of the widely expressed X-borne ATRX gene lies on the Y chromosome. Since mutations in human ATRX cause sex reversal, it is… CONTINUE READING