Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA

@article{Rodrx0301guezLpez2003CharacterisationOT,
  title={Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA},
  author={Ana M. Rodrıx0301guez-L{\'o}pez and D. Jackson and J. Nehlin and F. Iborra and A. V. Warren and L. Cox},
  journal={Mechanisms of Ageing and Development},
  year={2003},
  volume={124},
  pages={167-174}
}
Ageing is linked to the accumulation of replicatively senescent cells. The best model system to date for studying human cellular ageing is the progeroid Werner's syndrome (WS), caused by a defect in WRN, a recQ-like helicase that also possesses exonuclease activity. In this paper, we characterise the interaction between WRN and an essential replication factor, PCNA. We show that wild-type WRN protein physically associates with PCNA at physiological protein concentrations in normal cells, while… Expand
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