Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids.

@article{Alcal2003CharacterisationOT,
  title={Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids.},
  author={Maria del Mar Alcal{\'a} and Nuria Mar{\'i}a Vivas and Susana Hospital and Pelayo Camps and Diego Mu{\~n}oz-Torrero and A. Bernat Bad{\'i}a},
  journal={Neuropharmacology},
  year={2003},
  volume={44 6},
  pages={749-55}
}
The effects of two tacrine-huperzine A hybrids, (+/-)-huprine Y and (+/-)-huprine Z, have been evaluated. Bovine and human acetylcholinesterase (AChE) and human butyrylcholinesterase (BChE) inhibition were assayed by Ellman's method. The two huprines were more active than both tacrine and (-)-huperzine A as inhibitors of both human and bovine AChE, and they acted as mixed-type AChE inhibitors. Moreover, (+/-)-huprine Y exhibited a tight binding character seen in the experiments of reversibility… CONTINUE READING

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