Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula).

@article{Li2015CharacterisationOT,
  title={Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula).},
  author={Ronggai Li and Anthony K . Redmond and Tiehui Wang and Steve Bird and Helen Dooley and Christopher J Secombes},
  journal={Fish & shellfish immunology},
  year={2015},
  volume={47 1},
  pages={381-9}
}
The tumour necrosis factor superfamily (TNFSF) members CD40L and BAFF play critical roles in mammalian B cell survival, proliferation and maturation, however little is known about these key cytokines in the oldest jawed vertebrates, the cartilaginous fishes. Here we report the cloning of CD40L and BAFF orthologues (designated ScCD40L and ScBAFF) in the small-spotted catshark (Scyliorhinus canicula). As predicted both proteins are type II membrane-bound proteins with a TNF homology domain in… CONTINUE READING