Characterisation of the PTEN inhibitor VO-OHpic.

  title={Characterisation of the PTEN inhibitor VO-OHpic.},
  author={Lok Hang Mak and Ramon Vilar and Rudiger Woscholski},
  journal={Journal of chemical biology},
  volume={3 4},
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a phosphatidylinositol triphosphate 3-phosphatase that counteracts phosphoinositide 3-kinases and has subsequently been implied as a valuable drug target for diabetes and cancer. Recently, we demonstrated that VO-OHpic is an extremely potent inhibitor of PTEN with nanomolar affinity in vitro and in vivo. Given the importance of this inhibitor for future drug design and development, its mode of action needed to be elucidated. It… CONTINUE READING

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