Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study.

@article{Bielaszewska2011CharacterisationOT,
  title={Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study.},
  author={Martina Bielaszewska and Alexander Mellmann and Wenlan Zhang and Robin K{\"o}ck and Angelika Fruth and Andreas Bauwens and Georg Peters and Helge Karch},
  journal={The Lancet. Infectious diseases},
  year={2011},
  volume={11 9},
  pages={
          671-6
        }
}
BACKGROUND In an ongoing outbreak of haemolytic uraemic syndrome and bloody diarrhoea caused by a virulent Escherichia coli strain O104:H4 in Germany (with some cases elsewhere in Europe and North America), 810 cases of the syndrome and 39 deaths have occurred since the beginning of May, 2011. We analysed virulence profiles and relevant phenotypes of outbreak isolates recovered in our laboratory. METHODS We analysed stool samples from 80 patients that had been submitted to the National… Expand
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany.
TLDR
The findings suggest that horizontal genetic exchange allowed for the emergence of the highly virulent Shiga-toxin-producing enteroaggregative E. coli O104:H4 strain that caused the German outbreak, and highlight the way in which the plasticity of bacterial genomes facilitates the emerged of new pathogens. Expand
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G sequenced the genomes of isolates from five recent cases and compared them with historical isolates show that these recent isolates are not derived from the outbreak strain but are very closely related and share many of the same disease-causing genes, emphasizing the concern that these bacteria may cause future severe outbreaks. Expand
Molecular epidemiology of a household outbreak of Shiga-toxin-producing Escherichia coli in Poland due to secondary transmission of STEC O104:H4 from Germany.
We characterized two STEC O104 : H4 clinical isolates collected in Poland from a 7-year-old boy with haemolytic uraemic syndrome (HUS) and his nanny. This household outbreak began on 29 May 2011.Expand
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A Shiga-toxin-producing Escherichia coli (STEC) strain belonging to serotype O104:H4, phylogenetic group B1 and sequence type ST678, with virulence features common to the enteroaggregative E. coliExpand
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TLDR
The challenge of detection and confirmation of epidemic infections caused by atypical STEC strains and the benefits of coordinated EU laboratory networks to strengthen capabilities in response to a major outbreak are highlighted. Expand
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TLDR
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TLDR
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TLDR
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