Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.

@article{Sethi2000CharacterisationOR,
  title={Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.},
  author={Jaswinder K Sethi and Hai-dong Xu and K. Teoman Uysal and Sarah M. Wiesbrock and Ludger Scheja and G{\"o}khan S Hotamisligil},
  journal={FEBS letters},
  year={2000},
  volume={469 1},
  pages={77-82}
}
Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including adipocytes through its two distinct cell surface receptors. To address the role of each TNF receptor in the biological actions of TNFalpha in adipocytes, we have developed four new preadipocyte cell lines. These were established from wild type controls (TNFR1(+/+)R2(+/+)) and from mice lacking TNFR1 (TNFR1(-/-)), TNFR2 (TNFR2(-/-)) or both… CONTINUE READING

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