Characterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain

@article{Lehnert2012CharacterisationOP,
  title={Characterisation of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain},
  author={Wencke Lehnert and Marie Claude Gr{\'e}goire and Anthonin Reilhac and Steven R. Meikle},
  journal={NeuroImage},
  year={2012},
  volume={60},
  pages={2144-2157}
}
Accurate quantification of PET imaging data is required for a useful interpretation of the measured radioactive tracer concentrations. The partial volume effect (PVE) describes signal dilution and mixing due to spatial resolution and sampling limitations, which introduces bias in quantitative results. In the present study we investigated the magnitude of PVE for volumes of interest (VOIs) in the rat brain and the effect of positron range. In simulated (11)C-raclopride studies we examined the… CONTINUE READING
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