Characterisation of novel defective thiopurine S-methyltransferase allelic variants.

Abstract

Human thiopurine S-methyltransferase (TPMT, EC 2.1.1.67) is a key enzyme in the detoxification of thiopurine drugs widely used in the treatment of various diseases, such as inflammatory bowel diseases, acute lymphoblastic leukaemia and rheumatic diseases. The TPMT gene is genetically polymorphic and the inverse relationship between TPMT activity and the… (More)
DOI: 10.1016/j.bcp.2008.05.009

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