Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis

@article{Logan2007CharacterisationOM,
  title={Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis},
  author={Richard Logan and Rachel Gibson and Joanne M Bowen and Andrea M Stringer and Stephen T. Sonis and Dorothy Mary Kate Keefe},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={62},
  pages={33-41}
}
PurposeThe pathobiology of alimentary tract (AT) mucositis is complex and there is limited information about the events which lead to the mucosal damage that occurs during cancer treatment. Various transcription factors and proinflammatory cytokines are thought to play important roles in pathogenesis of mucositis. The aim of this study was to determine the expression of nuclear factor-κB (NF-κB), tumor necrosis factor (TNF) and interleukins-1β (IL-1β) and -6 (IL-6) in the AT following the… CONTINUE READING

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