Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity

@article{Jones2004CharacterisationOM,
  title={Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity},
  author={Donald J. L. Jones and John H. Lamb and Richard D. Verschoyle and Lynne M Howells and Michael Butterworth and C K Lim and David Ferry and Peter B. Farmer and Andreas J. Gescher},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={1213 - 1219}
}
Quercetin (3,5,7,3′,4′-pentahydroxyflavone) is a flavone with putative ability to prevent cancer and cardiovascular diseases. Its metabolism was evaluated in rats and human. Rats received quercetin via the intravenous (i.v.) route and metabolites were isolated from the plasma, urine and bile. Analysis was by high-performance liquid chromatography and confirmation of species identity was achieved by mass spectrometry. Quercetin and isorhamnetin, the 3′-O-methyl analogue, were found in both the… CONTINUE READING