Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways

@inproceedings{Hughes2016CharacterisationOL,
  title={Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways},
  author={Steven Hughes and Jessica Rodgers and Doron Hickey and Russell G Foster and Stuart N Peirson and Mark W. Hankins},
  booktitle={Scientific reports},
  year={2016}
}
Gnat(-/-), Cnga3(-/-), Opn4(-/-) triple knockout (TKO) mice lack essential components of phototransduction signalling pathways present in rods, cones and photosensitive retinal ganglion cells (pRGCs), and are therefore expected to lack all sensitivity to light. However, a number of studies have shown that light responses persist in these mice. In this study we use multielectrode array (MEA) recordings and light-induced c-fos expression to further characterise the light responses of the TKO… CONTINUE READING
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