Characterisation of human cells transformed in vitro by urethane

@article{Benedict1975CharacterisationOH,
  title={Characterisation of human cells transformed in vitro by urethane},
  author={William F. Benedict and Peter A. Jones and Walter E. Laug and Howard J. Igel and Aaron E. Freeman},
  journal={Nature},
  year={1975},
  volume={256},
  pages={322-324}
}
CELLS derived from several animal species, including mouse1,2, hamster3 and rat4, have been transformed in vitro from the normal to the malignant state by diverse chemical carcinogens. In similar conditions, however, attempts to transform human cells have usually been unsuccessful and as far as we know, such transformation has been reported only once5. This… CONTINUE READING