Characterisation of hoxa gene expression in the chick limb bud in response to FGF.

@article{Vargesson2001CharacterisationOH,
  title={Characterisation of hoxa gene expression in the chick limb bud in response to FGF.},
  author={Neil Vargesson and Konstadina Kostakopoulou and Garyfalia Drossopoulou and Spyros Papageorgiou and Cheryll Tickle},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2001},
  volume={220 1},
  pages={87-90}
}
We tested a diffusion gradient model for setting up overlapping domains of Hoxa gene expression in the chick limb bud. The model is based on morphogen production at the limb bud tip where the apical ridge is located and assumes that cells respond to a series of concentration thresholds. Consistent with the model, Hoxa13 gene expression rapidly switches off when the ridge is removed from stage 21/22 buds, while Hoxa11 and Hoxa10 expression is stable; Hoxa13 expression can be initiated and… CONTINUE READING
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