Characterisation of chondrocyte activation in response to cytokines synthesised by a synovial cell line.

@article{Sung1988CharacterisationOC,
  title={Characterisation of chondrocyte activation in response to cytokines synthesised by a synovial cell line.},
  author={K Sung and Deanna Mendelow and Helga I. Georgescu and Christopher H. Evans},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={971 2},
  pages={148-56}
}
The lapine, synovial cell line, HIG-82, secretes 'chondrocyte activating factors' (CAF) which induce the synthesis of collagenase (EC 3.4.24.7), gelatinase, caseinase and prostaglandin E2 (PGE2) by confluent, monolayer cultures of lapine, articular chondrocytes. Partially purified CAF increased the production of PGE2 by chondrocytes within 3 h; in certain cultures this occurred in as little as 1 h. Increased levels of the three neutral metalloproteinases, in contrast, were only measurable in… CONTINUE READING