Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry.

@article{Baar2002CharacterisationOB,
  title={Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry.},
  author={Ben M L van Baar and Albert G. Hulst and Ad L de Jong and Eric R. J. Wils},
  journal={Journal of chromatography. A},
  year={2002},
  volume={970 1-2},
  pages={
          95-115
        }
}
A method earlier developed for the mass spectrometric (MS) identification of tetanus toxin (TTx) was applied to botulinum toxins type A and B (BTxA and BTxB). Botulinum toxins are extremely neurotoxic bacterial toxins, likely to be used as biological warfare agent. Biologically active BTxA and BTxB are comprised of a protein complex of the respective neurotoxins with specific haemagglutinins (HAs) and non-toxic non-haemagglutinins (NTNHs). These protein complexes are also observed in mass… CONTINUE READING
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