Characterisation of an amphioxus Fringe gene and the evolution of the vertebrate segmentation clock

@article{Mazet2003CharacterisationOA,
  title={Characterisation of an amphioxus Fringe gene and the evolution of the vertebrate segmentation clock},
  author={Francoise Mazet and Sebastian M Shimeld},
  journal={Development Genes and Evolution},
  year={2003},
  volume={213},
  pages={505-509}
}
In mouse and chick embryos, cyclic expression of lunatic fringe has an important role in the regulation of mesoderm segmentation. We have isolated a Fringe gene from the protochordate amphioxus. Amphioxus is the closest living relative of the vertebrates, and has mesoderm that is definitively segmented in a manner that is similar to, and probably homologous with, that of vertebrates. AmphiFringe is placed basal to vertebrate Fringe genes in molecular phylogenetic analyses, indicating that the… CONTINUE READING

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