Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis.

@article{Walker2007CharacterisationOA,
  title={Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis.},
  author={Jennifer G. Walker and Michael John Ahern and Morton Coleman and Helen M Weedon and Virginia Papangelis and Dimitra Beroukas and Peter Roberts-Thomson and Malcolm D. Smith},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 8},
  pages={992-9}
}
OBJECTIVES To characterise the phenotype of the putative dendritic cells strongly expressing Jak3 and STAT4, which have been previously identified in the synovial tissue of patients with active rheumatoid arthritis (RA). METHODS Synovial biopsy specimens were obtained at arthroscopy from 30 patients with active RA (42 synovial biopsies). Immunohistological analysis was performed using monoclonal antibodies to detect dendritic cell subsets, including activation markers and cytokines relevant… CONTINUE READING

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