Characterisation of Weibel–Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis

@inproceedings{Cookson2013CharacterisationOW,
  title={Characterisation of Weibel–Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis},
  author={Emma A. Cookson and Ianina L. Conte and J. Dempster and M. J. Hannah and Tom Carter},
  booktitle={Journal of cell science},
  year={2013}
}
Regulated secretion from endothelial cells is mediated by Weibel-Palade body (WPB) exocytosis. Plasma membrane cholesterol is implicated in regulating secretory granule exocytosis and fusion pore dynamics; however, its role in modulating WPB exocytosis is not clear. To address this we combined high-resolution electrochemical analysis of WPB fusion pore dynamics, by amperometry, with high-speed optical imaging of WPB exocytosis following cholesterol depletion or supplementation in human… CONTINUE READING

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