Characterisation of P2Y12 Receptor Responsiveness to Cysteinyl Leukotrienes

  title={Characterisation of P2Y12 Receptor Responsiveness to Cysteinyl Leukotrienes},
  author={Holly Rebecca Foster and Elisabeth Fuerst and Tak Hong Lee and Davis J. Cousins and Grzegorz Woszczek},
  booktitle={PloS one},
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and inflammatory cell influx to the lung. A recent study has suggested that the purinergic receptor P2Y12 is required for LTE4 mediated pulmonary inflammation in a mouse model of asthma and signals in response to cysLTs. The aim of the study was to… CONTINUE READING
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