Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts.

@article{Shamraj1993CharacterisationON,
  title={Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts.},
  author={Olga Shamraj and Ingrid L. Grupp and G. Grupp and David Skene Melvin and Nathalie Gradoux and Walter Karl Kremers and Jerry B. Lingrel and Alain de Pover},
  journal={Cardiovascular research},
  year={1993},
  volume={27 12},
  pages={
          2229-37
        }
}
OBJECTIVE The aim was to determine whether failing human hearts have increased sensitivity to the inotropic and toxic effects of ouabain, and to examine alterations in Na/K-ATPase that might explain the observed higher ouabain sensitivity. METHODS For contractility studies, a total of 57 trabeculae were isolated from two non-failing (death from head injury) and 10 terminally failing, explanted human hearts. After the experiment, each trabecula was inspected under the light microscope for… CONTINUE READING
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