Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.

@article{Vetter2012CharacterisationON,
  title={Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.},
  author={Irina Vetter and Christine A. Mozar and Thomas Durek and Joshua S. Wingerd and Paul F Alewood and Macdonald J Christie and Richard J Lewis},
  journal={Biochemical pharmacology},
  year={2012},
  volume={83 11},
  pages={
          1562-71
        }
}
The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. The aim of this study was to determine the expression of endogenous Na(v) α and β subunits in SH-SY5Y cells using PCR and immunohistochemical approaches, and pharmacologically characterise the Na(v) isoforms endogenously expressed in this cell line using electrophysiological and… CONTINUE READING
Highly Cited
This paper has 31 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Allergy and Respiration

Advances in Experimental Medicine and Biology • 2016

References

Publications referenced by this paper.
Showing 1-10 of 36 references

A novel peptide from funnel web spider venom, omega-Aga-TK, selectively blocks, P-type calcium channels.

Biochemical and biophysical research communications • 1993
View 5 Excerpts
Highly Influenced

Assay dependent activity of the sodium channel gating modifier protoxin-I: implications for sodium channel drug discovery

A Bhattacharya, Q Wang, N Wu, AD. Wickenden
FASEB J 2009;23:998.31 • 2009
View 1 Excerpt