Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.

  title={Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.},
  author={Irina Vetter and Christine A. Mozar and Thomas Durek and Joshua S. Wingerd and Paul F Alewood and Macdonald J Christie and Richard J Lewis},
  journal={Biochemical pharmacology},
  volume={83 11},
The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. The aim of this study was to determine the expression of endogenous Na(v) α and β subunits in SH-SY5Y cells using PCR and immunohistochemical approaches, and pharmacologically characterise the Na(v) isoforms endogenously expressed in this cell line using electrophysiological and… CONTINUE READING
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