Characterisation of Lafora-like bodies and other polyglucosan bodies in two aged dogs with neurological disease.

@article{Mrquez2010CharacterisationOL,
  title={Characterisation of Lafora-like bodies and other polyglucosan bodies in two aged dogs with neurological disease.},
  author={Mercedes Roc{\'i}o Gonzales M{\'a}rquez and Lola P{\'e}rez and Anna M. Serafin and Susana Teijeira and Carmen Navarro and Mart{\'i} Batlle Pumarola},
  journal={Veterinary journal},
  year={2010},
  volume={183 2},
  pages={222-5}
}
Canine Lafora disease is a genetic disorder of carbohydrate metabolism characterised by neurological signs and accumulation of a type of polyglucosan body (PGB), the Lafora body (LB), in the brain and other organs. Normal canine ageing is associated with accumulation of PGBs in the brain, especially those corresponding to corpora amylacea (CA). In this study, two aged dogs that presented with progressive tremors, ataxia and paraplegia had abundant PGBs throughout the brain, mainly in the… CONTINUE READING