Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins.

  title={Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins.},
  author={Josephine C. Adams and R. Richard Monk and Amanda L. Taylor and Suat Ozbek and Nora Fascetti and Stefan Baumgartner and J{\"u}rgen Engel},
  journal={Journal of molecular biology},
  volume={328 2},
Thrombospondins (TSPs) are multidomain oligomers that have complex roles in cell interactions and tissue organisation. The five vertebrate TSPs comprise two subgroups, A and B, that are assembled as trimers or pentamers, respectively. An invertebrate TSP was recently discovered in Drosophila melanogaster, but there is no knowledge of the oligomerisation status or properties of this molecule. We developed by bioinformatics a new dataset containing the single TSP of Drosophila melanogaster and… CONTINUE READING

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