Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.

@article{Georgas2000CharacterisationOC,
  title={Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.},
  author={Kylie M. Georgas and Jo Bowles and Toshiya Yamada and Peter Koopman and Melissa H Little},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2000},
  volume={219 4},
  pages={582-7}
}
The Crim1 gene encodes a putative transmembrane protein with an IGF-binding protein motif and multiple chordin-like cysteine-rich repeats. In chordin, such repeats are responsible for its dorsalising activity and for binding to bone morphogenic proteins (BMPs). Crim1 displays a dynamic expression pattern in a variety of developing organs, including the CNS and the lens. We have undertaken a detailed expression pattern analysis of Crim1 in the developing mouse urogenital system. During… CONTINUE READING

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