Characterisation of ATP analogues to cross-link and label P2X receptors

  title={Characterisation of ATP analogues to cross-link and label P2X receptors},
  author={Kelvin C. Agboh and Andrew J. Powell and Richard J. Evans},
P2X receptors are a distinct family of ATP-gated ion channels with a number of physiological roles ranging from smooth muscle contractility to the regulation of blood clotting. In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2',3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors. These analogues were agonists, and in patch clamp studies evoked inward currents from HEK293 cells stably… CONTINUE READING


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