Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor.

@article{Wakamatsu1997CharacterisationOA,
  title={Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor.},
  author={Kazumasa Wakamatsu and Alison J Graham and Denise Cook and Anthony John Thody},
  journal={Pigment cell research},
  year={1997},
  volume={10 5},
  pages={288-97}
}
Alpha-Melanocyte-stimulating hormone (alpha-MSH) is a proopiomelanocortin (POMC)-derived peptide, which is produced in the pituitary and at other sites including the skin. It has numerous effects and in the skin has a pigmentary action through the activation of the melanocortin-1 (MC-1) receptor, which is expressed by melanocytes. Recent evidence suggests that the related POMC peptides such as adrenocorticotrophin (ACTH), which is the precursor of alpha-MSH, is also an agonist at the MC-1… CONTINUE READING

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