Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.

@article{Holbrook2009CharacterisationO5,
  title={Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.},
  author={Joanna D. Holbrook and Catherine H Gill and Noureddine Zebda and Jon Spencer and Rebecca Leyland and Kim H Rance and Han Trinh and Gemma Mary Balmer and Fiona M. Kelly and Shahnaz P. Yusaf and Nicola Courtenay and Jane E Luck and Andrew Rhodes and Sundip S Modha and Stephen E. Moore and Gareth John Sanger and Martin J. Gunthorpe},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 2},
  pages={384-96}
}
The 5-HT(3) receptor is a member of the 'Cys-loop' family of ligand-gated ion channels that mediate fast excitatory and inhibitory transmission in the nervous system. Current evidence points towards native 5-HT(3) receptors originating from homomeric assemblies of 5-HT(3A) or heteromeric assembly of 5-HT(3A) and 5-HT(3B). Novel genes encoding 5-HT(3C), 5-HT(3D), and 5-HT(3E) have recently been described but the functional importance of these proteins is unknown. In the present study, in silico… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…