Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies.

Abstract

The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were studied using purified synaptic plasma membranes prepared from rat cerebral cortex. In 10 mM HEPES buffer [3H]gabapentin bound to a single population of sites with high affinity (KD = 38 +/- 2.8 nM… (More)

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@article{SumanChauhan1993CharacterisationO, title={Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies.}, author={Nirmala Suman-Chauhan and L Webdale and David R. Hill and G. N. Woodruff}, journal={European journal of pharmacology}, year={1993}, volume={244 3}, pages={293-301} }