Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.

@article{Bailey2007CharacterisationO3,
  title={Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.},
  author={Andrew M. Bailey and Russell J Cox and Kate Harley and Colin Michael Lazarus and Thomas J Simpson and Elizabeth Julia Skellam},
  journal={Chemical communications},
  year={2007},
  volume={39},
  pages={
          4053-5
        }
}
Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release. 

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References Notes
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Multiple alignment of KS domains from Non-reducing Clade III PKS

Multiple alignment of KS domains from Non-reducing Clade III PKS