Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

@inproceedings{Bujalska2007CharacterisationO1,
  title={Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat},
  author={Iwona J. Bujalska and Omar M. Durrani and Joseph A. Abbott and Claire Uchechukwu Onyimba and Pamela Khosla and Areeb H Moosavi and Tristan T. Q. Reuser and Paul Michael. Stewart and J W Tomlinson and Elizabeth Anne Walker and Saaeha Rauz},
  booktitle={The Journal of endocrinology},
  year={2007}
}
Glucocorticoids (GCs) have a profound effect on adipose biology increasing tissue mass causing central obesity. The pre-receptor regulation of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) that activates cortisol from cortisone has been postulated as a fundamental mechanism underlying the metabolic syndrome mediating adipocyte hyperplasia and hypertrophy in the omental (OM) depot. Orbital adipose tissue (OF) is the site of intense inflammation and tissue remodelling in several… CONTINUE READING

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