Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes.

@article{Finlayson2001CharacterisationO,
  title={Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes.},
  author={Keith Finlayson and Joyce Ann MCLUCKIE and Jonathan David Hern and Ichiro Aramori and Henry J. Olverman and John B. Kelly},
  journal={Neuropharmacology},
  year={2001},
  volume={41 3},
  pages={341-50}
}
The pharmacology of [(125)I]-apamin binding sites was examined in rat cortical and hippocampal tissue and compared with membranes prepared from human embryonic kidney (HEK293) cells transfected with SK channel subtypes hSK1, rSK2 and rSK3. The K(D) of [(125)I]-apamin in rat cortex and hippocampus was similar to the apamin-sensitive subtypes, rSK2 and rSK3… CONTINUE READING