Characterisation and distribution of inositol polyphosphate and Ryanodine receptors in the rat brain.

@article{Smith1993CharacterisationAD,
  title={Characterisation and distribution of inositol polyphosphate and Ryanodine receptors in the rat brain.},
  author={Sean M. Smith and Stefan R. Nahorski},
  journal={Journal of neurochemistry},
  year={1993},
  volume={60 5},
  pages={
          1605-14
        }
}
The regional distribution of inositol 1,4,5-trisphosphate (InsP3), inositol 1,3,4,5-tetrakisphosphate (InsP4), and ryanodine binding sites has been characterised and compared in the rat brain using radioligand binding assays. Cortical [3H]InsP3 binding indicated similar positional and stereospecificity as observed in other tissues, with 100-fold selectivity for InsP3 over InsP4. Similarly, high-affinity [32P]InsP4 binding also showed a high degree of positional specificity, with a 1,000-fold… CONTINUE READING

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