Characterisation and Prediction of Phase Separation in Hot-Melt Extruded Solid Dispersions: A Thermal, Microscopic and NMR Relaxometry Study

Abstract

To develop novel analytical approaches for identifying both miscibility and phase separation in hot-melt extruded formulations. Felodipine-Eudragit® E PO solid dispersions were prepared using hot-melt extrusion. The fresh and aged formulations were characterised using scanning electron microscopy, differential scanning calorimetry, heat capacity (Cp… (More)
DOI: 10.1007/s11095-010-0185-8

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8 Figures and Tables