Chapter 4 Patch clamp techniques for single channel and whole-cell recording

@inproceedings{Ogden1999Chapter4P,
  title={Chapter 4 Patch clamp techniques for single channel and whole-cell recording},
  author={David Ogden and Peter R. Stanfield},
  year={1999}
}
The patch clamptechnique was first used by Neher and Sakmann (1976) to resolve currents through single acetylcholine-activated channels in cell-attached patches of membrane of frog skeletal muscle. The method they used (described by Neher, Sakmann & Steinbach, 1978) and subsequent refinements (Hamill, Marty, Neher, Sakmann & Sigworth, 1981) have led to techniques for high resolution recording of current in excised membrane patches in addition to those that remain cell-attached. Single channel… CONTINUE READING

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