Chapter 3 Population Genetics of Neoplasms

  title={Chapter 3 Population Genetics of Neoplasms},
  author={Andrea Sottoriva and Simon Tavar{\'e}},
Cancer is a complex disease of the genome that arises from the interplay of numerous underlying biological processes occurring within and between cells. Cancer population genetics aims at investigating malignant dynamics by studying the distribution of somatic alterations in cancer cell populations. Such aberrant DNA modifi cations lead to the development of cellular malignant traits like cancer invasion, metastasis and therapy resistance. The study of population genetics in neoplasms… CONTINUE READING


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