Corpus ID: 46610816

Chapter 3 Methods for Predicting RNA Secondary Structure

  title={Chapter 3 Methods for Predicting RNA Secondary Structure},
  author={Kornelia Aigner and F. Dre{\ss}en and G. Steger},
The formation of RNA structure is a hierarchical process: the secondary structure builds up by thermodynamically favorable stacks of base pairs (helix formation) and unfavorable loops (non-Watson–Crick base pairs; hairpin, internal, and bulge loops; junctions). The tertiary structure folds on top of the thermodynamically optimal or close-to-optimal secondary structure by formation of pseudoknots, base triples, and/or stacking of helices. In this chapter, we will concentrate on available… CONTINUE READING

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