Chapter 23 Quantification of superoxide production by mouse brain and skeletal muscle mitochondria.

@article{Maliska2009Chapter2Q,
  title={Chapter 23 Quantification of superoxide production by mouse brain and skeletal muscle mitochondria.},
  author={Dominika Malińska and Alexei P. Kudin and Grazyna Debska-Vielhaber and Stefan Vielhaber and Wolfram S Kunz},
  journal={Methods in enzymology},
  year={2009},
  volume={456},
  pages={
          419-37
        }
}
The production of reactive oxygen species (ROS) has been implicated for numerous pathologic alterations, including neurodegeneration and aging. They are formed to a considerable extent by mitochondria by single electron reduction of molecular oxygen by competent electron donors like flavoproteins and semiubiqunone species. In this chapter, we evaluate quantitative methods for the detection of hydrogen peroxide and superoxide production. Applying these methods we compared the ROS production of… CONTINUE READING

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