Chapter 16 – Hereditary Spastic Paraplegia

  title={Chapter 16 – Hereditary Spastic Paraplegia},
  author={H S Singer and Jonathan W. Mink and Donald L Gilbert and Joseph Jankovic},
This chapter discusses the large variety of heritable diagnoses in childhood where spastic paraplegia is the prominent feature. Spastic paraplegia in childhood is most often due to periventricular injury associated with premature birth. The focus of this chapter is the clinical presentation, pathophysiology, and genetics of hereditary spastic paraplegias (HSPs), which can have autosomal recessive, autosomal dominant, or mitochondrial inheritance. The HSPs are classified as “pure” or… CONTINUE READING

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