Chapter 15: Disease Gene Prioritization

  title={Chapter 15: Disease Gene Prioritization},
  author={Yana Bromberg},
  booktitle={PLoS Computational Biology},
Disease-causing aberrations in the normal function of a gene define that gene as a disease gene. Proving a causal link between a gene and a disease experimentally is expensive and time-consuming. Comprehensive prioritization of candidate genes prior to experimental testing drastically reduces the associated costs. Computational gene prioritization is based on various pieces of correlative evidence that associate each gene with the given disease and suggest possible causal links. A fair amount… CONTINUE READING
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