Chapter 13. Bacterial Penicillin-Binding Proteins

@inproceedings{Georgopapadakou1983Chapter1B,
  title={Chapter 13. Bacterial Penicillin-Binding Proteins},
  author={Nafsika H. Georgopapadakou},
  year={1983}
}
Publisher Summary Penicillin and other β-lactam antibiotics inhibit bacterial growth by binding to specific transpeptidases that crosslink peptidoglycan, the rigid bag-like macromolecule, responsible for the mechanical strength of the bacterial envelope. Penicillin acts as a steric analogue of the pentapeptide chain in growing peptidoglycan, forming a stable penicilloyl–enzyme complex with peptidoglycan transpeptidase. In contrary to the steric analogue model, penicillin acts as a transition… CONTINUE READING

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